When you run an optimization, current settings on the Options panel and Advanced Options dialog are automatically saved in a preference file and will be applied to future optimizations.
Other settings — such as objectives, requirements, and constraint definitions — are saved in the primary workbook selected in the dropdown list on the Objectives panel. They are saved to the workbook when the optimization runs, however they are not saved permanently until you save the primary workbook itself.
If you choose to copy optimization values to the model, these values are displayed as the new cell values and are also saved when the model is saved. Each workbook can have one set of optimization settings.
If you click Close in the OptQuest wizard before you run an optimization, OptQuest asks whether to save the settings. If you respond Yes, current settings are saved to the workbook. Otherwise, current settings are discarded and the last saved settings remain.